Green Techniques for Organic Synthesis and Medicinal Chemistry

Wei Zhang 지음

Wiley 2012년 05월 10일 출간

작품소개

책소개

Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes.Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts:Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry.Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions.Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors.Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry.Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, RD professionals and students working in organic chemistry and medicinal chemistry.

목차

List of Contributors xixI INTRODUCTION 11 Green Toxicology 3Nicholas D. Anastas1.1 Introduction 31.2 History and Scope of Toxicology 41.2.1 The need for green toxicology 51.3 Principles of Toxicology 51.3.1 Characteristics of exposure 61.3.2 Spectrum of toxic effects 61.3.3 The dose&~response relationship 71.4 Disposition of Toxicants in Organisms 81.4.1 Absorption 91.4.2 Distribution 111.4.3 Metabolism 111.4.4 Excretion 121.5 Nonorgan System Toxicity 121.5.1 Carcinogenesis 131.5.2 Reproductive and developmental toxicity 131.5.3 Immunotoxicology 141.6 Mechanistic Toxicology 151.7 Quantitative Structure&~Activity Relationships 161.8 Environmental Toxicology 181.8.1 Persistence and bioaccumulation 181.9 Risk Assessment 191.9.1 NonCancer risk assessment 201.9.2 Cancer risk assessment 211.10 Conclusions 21References 222 Green Chemistry and the Pharmaceutical Industry 25Amy S. Cannon, Joseph L. Pont and John C. Warner2.1 Introduction 252.2 Green Chemistry versus Sustainable Chemistry 262.3 Trend: The Ongoing Use of Hazardous Chemistry 272.4 Myth: To Do Green Chemistry One Must Sacrifice Performance and Cost 282.5 Green Chemistry and the Future of the Pharmaceutical Industry 292.6 Green Chemistry in Pharmaceutical Process Development and Manufacturing 302.7 Conclusions 30References 31II GREEN CATALYSIS 333 Environmental Science and Green Chemistry; Guiding Environmentally PreferredManufacturing, Materials, and Products 35Richard T. Williams and Travis R. Williams3.1 Introduction 353.2 Market Forces 363.2.1 Chemicals in the natural and human environment 373.2.2 Precautionary decision making 373.2.3 Chemical control laws 373.2.4 Green chemistry initiatives 383.2.5 Drug registration Environmental Risk Assessment (ERA) 393.2.6 Extended Producer Responsibility (EPR) 393.2.7 Ecosystem valuation 393.2.8 Company expe

출판사 서평

“In summary, the book covers new advances in green chemistry, which are applied in the pharmaceutical industry.& It also shows ways of introducing innovation in a more holistic manner, through the development of smart equipment, techniques, or innovative chemicals.”& (Green Processing and Synthesis, 1 August 2012)

작가정보

저자(글) Wei Zhang