Intelligent Surfaces in Biotechnology

H. Michelle Grandin 지음

Wiley 2012년 02월 03일 출간

작품소개

책소개

A comprehensive overview of smart and responsive surfaces in biotechnology and their applicationsA wave of recent advances in cell biology, biophysics, chemistry, and materials science has enabled the development of a new generation of smart biomaterials. Intelligent Surfaces in Biotechnology: Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications provides readers with a comprehensive overview of surface modifications and their applications, including coverage of the physico-chemical properties, characterization methods, smart coating technologies, and demonstration of performance in vitro and in vivo.The first part of the book covers applications in the fields of biosensing and biodiagnostics, while the second part focuses more on coatings for medical devices, drug delivery, and tailored cell-surface interactions. The book explores intelligent surface applications such as tissue engineering, drug targeting and delivery, wound healing and anti-infection strategies, biosensors, nanopatterning, and bioinspired design of novel responsive materials and multifunctional surfaces.Designed to aid scientists and engineers in understanding the rapidly developing field of biofunctional surfaces, Intelligent Surfaces in Biotechnology is an edited volume with each chapter written by a respected expert and featuring examples taken from the most state-of-the-art developments in the discipline.Cover Image: Design concept for a diagnostic microfluidic system based on responsive polymer- and antibody-conjugated nanobeads (see Chapter 2 of this book, Figure 2.5; reproduced by permission from the Royal Society of Chemistry).

목차

Foreword xvPreface xixContributors xxiii1. Stimulus-Responsive Polymers as Intelligent Coatings for Biosensors: Architectures, Response Mechanisms, and Applications 1Vinalia Tjong, Jianming Zhang, Ashutosh Chilkoti, and Stefan Zauscher1.1 Introduction 11.2 SRP Architectures for Biosensor Applications 21.2.1 Cross-Linked Polymer Networks (Hydrogels) 21.2.2 End-Grafted Polymer Chains (Polymer Brushes) 51.2.3 Self-Assembled Polyelectrolyte (PEL) Multilayers (LBL Thin Films) 51.2.4 Molecularly Imprinted Polymers 61.2.5 Hybrid Coatings 61.3 Mechanisms of Response 61.3.1 Sensing Selectivity 61.3.2 Conformational Reorganization of SRP Coatings 71.3.2.1 Changes in Osmotic Swelling Pressure 71.3.2.2 Changes in Apparent Cross-Link Density 81.4 Sensing and Transduction Mechanisms 91.4.1 Optical Transduction 91.4.1.1 Examples of SRP Sensors That Use Optical Transduction Principles 111.4.2 Electrochemical Transduction 141.4.2.1 Examples of SRP Sensors That Use Electrochemical Transduction Principles 151.4.3 Mechanical Transduction 171.4.3.1 Examples of SRP Sensors That Use Mechanical Transduction Principles 181.5 Limitations and Challenges 191.5.1 LOD and Sensitivity 191.5.2 Selectivity 201.5.3 Working Range 201.5.4 Response Time 201.5.5 Reliability and Long-Term Stability 211.6 Conclusion and Outlook 22Acknowledgements 22References 222. Smart Surfaces for Point-of-Care Diagnostics 31Michael A. Nash, Allison L. Golden, John M. Hoffman, James J. Lai, and Patrick S. Stayton2.1 Introduction 312.1.1 POC Testing Challenges 322.2 Standard Methods for Biomarker Purification, Enrichment, and Detection 332.3 Smart Reagents for Biomarker Purification and Processing 342.3.1 IgG Antibody&~pNIPAAm Conjugates 382.3.2 Single-Chain Antibody&~pNIPAAm Conjugates 392.3.3 Nucleotide&~pNIPAAm Conjugates 402.3.4

출판사 서평

“The present book with its 350 pages is not a textbook but reading for experts and inspires scientists and engineers to further investigations to tackle the transition from synthetic to living materials, äs it is meant by the term "intelligent interfaces".& The presented "smart" biosensors and medical devices demonstrate nicely, how we can learn from nature and make profit of its impressive "inventions" in our modern life.”& (Tenside Surfactants Detergents, 1 May 2012)&

작가정보

저자(글) H. Michelle Grandin

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H. Michelle Grandin currently works as a scientific writer and consultant in the field of tissue regeneration and implant surfaces for dental applications. Previously, she worked as a senior research scientist in the biointerface group of Marcus Textor at ETH Zurich. There, she developed a waveguide fluorescence microscope for the study of bio-interactions in the near-field as well as leading a group in the development of 3D single cellular microwell arrays for application in stem cell and cancer research.Marcus Textor is a Professor Emeritus at ETH Zurich, Department of Materials. He was head of a research group dedicated to surfaces and interfaces in bio-related fields of material science. His research interests cover both fundamental aspects of the behavior of materials in contact with biological milieus and the design and development of surfaces that elicit biospecific responses.