Topical and Transdermal Drug Delivery

Heather A. E. Benson 지음

Wiley 2012년 02월 03일 출간

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책소개

Practical drug development approaches presented by leading expertsDesigned to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development.Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts:Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment.Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the scienc

목차

Preface ixAbout the Editors xiContributors xiiiPart One Current Science, Skin Permeation, and Enhancement Approaches1. Skin Structure, Function, and Permeation 3Heather A.E. Benson2. Passive Skin Permeation Enhancement 23Majella E. Lane, Paulo Santos, Adam C. Watkinson, and Jonathan Hadgraft3. Electrical and Physical Methods of Skin Penetration Enhancement 43Jeffrey E. Grice, Tarl W. Prow, Mark A.F. Kendall, and Michael S. Roberts4. Clinical Applications of Transdermal Iontophoresis 67Dhaval R. Kalaria, Sachin Dubey, and Yogeshvar N. Kalia5. In Vitro Skin Permeation Methodology 85Barrie Finnin, Kenneth A. Walters, and Thomas J. Franz6. Skin Permeation Assessment: Tape Stripping 109Sandra Wiedersberg and Sara Nicoli7. Skin Permeation Assessment: Microdialysis 131Rikke Holmgaard, Jesper B. Nielsen, and Eva Benfeldt8. Skin Permeation: Spectroscopic Methods 155Jonathan Hadgraft and Majella E. Lane9. Skin Permeation Assessment in Man: In Vitro&~In Vivo Correlation 167Paul A. Lehman, Sam G. Raney, and Thomas J. Franz10. Risk Assessment 183Jon R. HeylingsPart Two Topical and Transdermal Product Development11. An Overview of Product Development from Concept to Approval 203Adam C. Watkinson12. Regulatory Aspects of Drug Development for Dermal Products 217William K. Sietsema13. Toxicological and Pre-clinical Considerations for Novel Excipients and New Chemical Entities 233Andrew Makin and Jens Thing Mortensen14. Topical Product Formulation Development 255Marc B. Brown, Robert Turner, and Sian T. Lim15. Transdermal Product Formulation Development 287Kenneth J. Miller16. Sensitivity and Irritation Testing 309Belum Viswanath Reddy, Geetanjali Sethi, and Howard I. Maibach17. New Product Development for Transdermal Drug Deliver

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저자(글) Heather A. E. Benson

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Heather A. E. Benson, PhD, is an Associate Professor in the School of Pharmacy at Curtin University, Australia, where she leads the Skin Delivery Research Group. Internationally recognized for her research in skin biology and drug/peptide delivery, Dr. Benson has published more than 100 peer-reviewed publications on the topic of drug delivery.Adam C. Watkinson, MBA, PhD, has worked in topical and transdermal drug delivery for twenty-three years and played key roles in the development of Axiron (transdermal testosterone) and Sancuso (transdermal granisetron) while at Acrux and ProStrakan, respectively. He has published extensively on his research, is the author of several patents, and holds an Honorary Chair at the School of Pharmacy at the University of London. He runs Storith Consulting, a firm offering advice in the areas of drug development and topical and transdermal drug delivery.