Chemical Analysis of Antibiotic Residues in Food

Jian Wang 지음

Wiley 2011년 11월 29일 출간

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An insightful exploration of the key aspects concerning the chemical analysis of antibiotic residues in foodThe presence of excess residues from frequent antibiotic use in animals is not only illegal, but can pose serious health risks by contaminating products for human consumption such as meat and milk. Chemical Analysis of Antibiotic Residues in Food is a single-source reference for readers interested in the development of analytical methods for analyzing antibiotic residues in food. It covers themes that include quality assurance and quality control, antibiotic chemical properties, pharmacokinetics, metabolism, distribution, food safety regulations, and chemical analysis. In addition, the material presented includes background information valuable for understanding the choice of marker residue and target animal tissue to use for regulatory analysis. This comprehensive reference:Includes topics on general issues related to screening and confirmatory methodsPresents updated information on food safety regulation based on routine screening and confirmatory methods, especially LC-MSProvides general guidance for method development, validation, and estimation of measurement uncertaintyChemical Analysis of Antibiotic Residues in Food is written and organized with a balance between practical use and theory to provide laboratories with a solid and reliable reference on antibiotic residue analysis. Thorough coverage elicits the latest scientific findings to assist the ongoing efforts toward refining analytical methods for producing safe foods of animal origin.

목차

Preface xvAcknowledgment xviiEditors xixContributors xxi1 Antibiotics: Groups and Properties 1Philip Thomas Reeves1.1 Introduction, 11.1.1 Identification, 11.1.2 Chemical Structure, 21.1.3 Molecular Formula, 21.1.4 Composition of the Substance, 21.1.5 pKa, 21.1.6 UV Absorbance, 31.1.7 Solubility, 31.1.8 Stability, 31.2 Antibiotic Groups and Properties, 31.2.1 Terminology, 31.2.2 Fundamental Concepts, 41.2.3 Pharmacokinetics of Antimicrobial Drugs, 41.2.4 Pharmacodynamics of Antimicrobial Drugs, 51.2.4.1 Spectrum of Activity, 51.2.4.2 Bactericidal and Bacteriostatic Activity, 61.2.4.3 Type of Killing Action, 61.2.4.4 Minimum Inhibitory Concentration and Minimum Bactericidal Concentration, 71.2.4.5 Mechanisms of Action, 71.2.5 Antimicrobial Drug Combinations, 71.2.6 Clinical Toxicities, 71.2.7 Dosage Forms, 81.2.8 Occupational Health and Safety Issues, 81.2.9 Environmental Issues, 81.3 Major Groups of Antibiotics, 81.3.1 Aminoglycosides, 81.3.2 ß-Lactams, 101.3.3 Quinoxalines, 181.3.4 Lincosamides, 201.3.5 Macrolides and Pleuromutilins, 211.3.6 Nitrofurans, 271.3.7 Nitroimidazoles, 281.3.8 Phenicols, 301.3.9 Polyether Antibiotics (Ionophores), 311.3.10 Polypeptides, Glycopeptides, and Streptogramins, 351.3.11 Phosphoglycolipids, 361.3.12 Quinolones, 361.3.13 Sulfonamides, 441.3.14 Tetracyclines, 451.4 Restricted and Prohibited Uses of Antimicrobial Agents in Food Animals, 521.5 Conclusions, 52Acknowledgments, 53References, 532 Pharmacokinetics, Distribution, Bioavailability, and Relationship to Antibiotic Residues 61Peter Lees and Pierre-Louis Toutain2.1 Introduction, 612.2 Principles of Pharmacokinetics, 612.2.1 Pharmacokinetic Parameters, 612.2.2 Regulatory Guidelines on Dosage Selection for Efficacy, 642.2.3 Residue Concentrations in

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저자(글) Jian Wang

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JIAN WANG is currently a research scientist leading a research and development unit for the Canadian Food Inspection Agency in Calgary, Alberta. His responsibilities include planning and conducting research projects in method development for antibiotic and pesticide residues in foods using advanced mass spectral analysis techniques such as UPLC/Q-TOF and LC/ESI-MS/MS. He has written over thirty publications for various journals and books. He was most recently awarded the CFIA Science Branch Recognition Award for leading method development on melamine investigation in 2007.JAMES D. MacNEIL retired as head of the Centre for Veterinary Drug Residues of the Canadian Food Inspection Agency in 2007. His recent achievements include receiving the Joint FAO/WHO Expert Committee on Food Additives 50th Anniversary commemorative silver medal awarded in 2006 for services to JECFA; the Public Service of Canada Award of Excellence, a career achievement in 2007; and appointment as scientist emeritus by CFIA in 2008. He is the former scientific editor for quot;Drugs, Cosmetics, and Forensicsquot; of the Journal of AOAC International and the author of numerous publications on veterinary drug residue analysis. He is currently an adjunct professor in the Department of Chemistry, Saint Mary's University, Halifax, Canada.JACK F. KAY works in the UK Department for Environment, Food and Rural Affairs. He helped draft European Commission Decision 2002/657/EC and, in 2008, introduced joint auditing to this and ISO 17025 standards into a major UK laboratory. He has actively participated in the Codex Committee on Residues of Veterinary Drugs in Food for more than ten years and was appointed an expert advisor on honey to the Food and Agriculture Organization of the United Nations in 2008. Since 2005, he has held an Honorary Senior Research Fellowship in the Department of Mathematics and Statistics at the University of Strathclyde, Scotland.