Automation in Proteomics and Genomics

Gil Alterovitz 지음

Wiley 2009년 03월 16일 출간

작품소개

책소개

In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated.Automation in Proteomics Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include:molecular biology fundamentals: from -blueprint- (DNA) to -task list- (RNA) to -molecular machine- (protein); proteomics methods and technologies; modelling protein networks and interactionsanalysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networksdesign via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networksintegration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomicsnew enabling technologies and future applicationsAutomation in Proteomics Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.

목차

Preface.List of Contributors.About the Editors.SECTION 1 FUNDAMENTALS OF MOLECULAR AND CELLULAR BIOLOGY1 The Central Dogma: From DNA to RNA, and to Protein (Takashi Ohtsuki, Masahiko Sisido).2 Genomes to Proteomes (Ellen A. Panisko, Igor Grigoriev, Don S. Daly, Bobbie-Jo Webb-Robertson and Scott E. Baker).SECTION 2 ANALYSIS VIA AUTOMATION.3 High-Throughput DNA Sequencing (Tarjei S. Mikkelsen).4 Modeling a Regulatory Network Using Temporal Gene Expression Data: Why and How (Sophie L`ebre and Gäelle Lelandais)?5 Automated Prediction of Protein Attributes and Its Impact on Biomedicine and Drug Discovery (Kuo-Chen Chou).6 Molecular Interaction Networks: Topological and Functional Characterizations (Xiaogang Wu and Jake Y. Chen).SECTION 3 DESIGN VIA AUTOMATION.7 DNA Synthesis (Jingdong Tian).8 Computational and Experimental RNA Nanoparticle Design (Isil Severcan, Cody Geary, Luc Jaeger, Eckart Bindewald, Wojciech Kasprzak and Bruce A. Shapiro).9 New Paradigms in Droplet-Based Microfluidics and DNA Amplification (Michael L. Samuels, John Leamon, Jonathan Rothberg, Ronald Godiska,Thomas Schoenfeld and David Mead).10 Synthetic Networks (Jongmin Kim).SECTION 4 INTEGRATION.11 Molecular Modeling of CYP Proteins and its Implication for Personal Drug Design (Jing-Fang Wang, Cheng-Cheng Zhang, Jing-Yi Yan, Kuo-Chen Chou and Dong-Qing Wei).12 Recent Progress of Bioinformatics in Membrane Protein Structural Studies (Hong-Bin Shen, Jun-Feng Wang, Li-Xiu Yao, Jie Yang and Kuo-Chen Chou).13 Trends in Automation for Genomics and Proteomics (Gil Alterovitz, Roseann Benson, Marco Ramoni and Dmitriy Sonkin).Index.

작가정보

저자(글) Gil Alterovitz

저자 :

저자 :

저자 :

저자 :

저자 :
저자 :
저자 :
Gil AlterovitzDr. Alterovitz received his PhD in Electrical and biomedical Engineering at MIT through the Harvard/MIT Division of Health Sciences and Technology. He is a biomedical informatics fellow with the Harvard/MIT Division of Health Sciences and Technology (HST), Children's Hospital Informatics Program, and the Harvard Medical School-Partners Center for Genetics and Genomics. He is currently heading a new class that he initiated at Harvard University, bio.95hfa: 'Proteomics and Cellular Network Engineering'. He has served on the Harvard/MIT Division of Health Sciences and technology MD Curriculum and the Harvard/MIT Division of Health Sciences and Technology PhD Admission committees. He was a US Fulbright to Canada (University of Toronto) in 1998-1999. Dr Alterovitz has an S.M. Degree from the Massachusetts Institute of Technology (MIT) in Electrical Engineering and Computer Science, where he was a NDSEG Fellow. His B.S. is in Electrical and Computer Engineering from Carnegie Mellon University.Dr Alterovitz has worked at Motorola (where he won the Motorola Intellectual Property Award), at IBM, and as a consultant for several national clients. As an invited contributor, he wrote the 'Proteomics' section for the Wiley Encyclopedia of Biomedical Engineering. Dr Alterovitz has appeared or has been cited for achievements in several national media outlets, including three separate editions of USA Today and National Public Radio. He was also featured in the Boston Globe. In 2001, he was selected as one of approximately 20 international delegates to the Canada 25 forum (to discuss healthcare/technology) covered by CBC radio, a national V special and Canada's Maclean's.RoSeann BensonFor eleven years, Ms Benson was a chemical engineer, and participated in all phases of automation implementation projects in a variety of industries: nuclear, semiconductor, aluminum, specialty chemical and environmental. Her engineering experience ran the p