Molecular Therapeutics

Pamela Greenwell 지음

Wiley-Interscience 2008년 03월 11일 출간

작품소개

책소개

quot;This book should be useful to lecturers who teach senior undergraduates, graduate students, and students in the biomedical sciences in general. More globally, Greenwell and McCulley's book should encourage academicians of any stripe who for some time have been honing their lectures in a niche subject area to turn their courses into textbooks.quot; ~Biochemistry and Molecular Biology EducationMolecular therapeutics refers to the developments in molecular biology that are focused on treating disease with new molecular-based drugs.By taking advantage of recent advances and increased understanding in the field of human genetics, this book provides essential background knowledge and key literature on a broad range of novel approaches and disciplines. These include making recombinant proteins, xenotransplantation gene therapy and therapeutic cloning. Molecular Therapeutics: 21st Century Medicine describes the techniques - including their associated benefits, problems, pitfalls - and discusses their applicability with respect to treating microbial, inherited, multifactoral and acquired diseases. The book also pays specific attention to the ethical issues associated with this new field.Cutting-edge topics and clinically relevant materialsengage and maintain student interestSelf-assessment questions are included throughout the bookFeatures an additional web site, with a web forum, regular updates and PowerPoint slides of figures from the bookMolecular Therapeutics: 21st Century Medicine is a comprehensive, accessible and engaging guide to the rapidly developing field of molecular therapeutics. It is essential reading for all students in this area of research and also of interest for health professionals involved in these novel therapies.

목차

Prologue1 Introduction1.1 Microbial diseases1.2 Cancer and heart disease1.3 Genetic diseases1.4 Role of molecular biology in therapeutics2 Prenatal diagnosis and pre-implementation2.1 Should we treat inherited diseases?2.2 Genetic screening2.2.1 Pre-implementation genetic diagnosis2.3 Counselling3 Simple protein replacement therapy3.1 Preventing transfusion-transmissible infectiousdiseases in the UK3.2 Ensuring the safety of organ transplants3.3 Preventing transfusion-transmissible infectiousdiseases worldwide3.4 HIV4 Recombinant protein production4.1 Choice of organism4.2 Alternatives to E. coli for the production ofrecombinant proteins4.3 Problems with recombinant protein production4.4 All recombinants must be tested before they aregiven to humans4.5 Why make recombinant proteins?4.6 Recombinant products4.7 Generics5 Recombinant vaccines5.1 Vaccine history5.2 Vaccines5.3 Vaccine methods5.4 Types of vaccine5.5 The limitations of vaccine programmes5.6 The role of the WHO5.7 Problems specific to developing countries5.8 Economics and logistics of vaccinology5.9 Recombinant vaccines5.10 Rational design: bioinformatics and proteomics5.11 Other interesting areas for vaccine development5.12 Conclusion6 Therapeutic antibodies and immunotherapy6.1 Monoclonal antibodies6.2 Monoclonal production6.3 Therapeutic monoclonal antibodies6.4 Transgenic monoclonals6.5 The uses of monoclonal antibodies in therapy6.6 Specific examples of therapeutic strategies6.7 Other recombinant proteins used in immunotherapy7 Transgenic animals7.1 Why do we want to engineer the genomes of animals?7.2 Experimental procedure7.3 DNA constructs, insertional mutagenesis andhomologous recombination7.4 Uses of inducible and

출판사 서평

"This book should be useful to lecturers who teach senior undergraduates, graduate students, and students in the biomedical sciences in general. More globally, Greenwell and McCulley's book should encourage academicians of any stripe who for some time have been honing their lectures in a niche subject area to turn their courses into textbooks." (Biochemistry and Molecular Biology Education, November/December 2008)

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저자(글) Pamela Greenwell

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Pamela Greenwell is Principal Lecturer at The University of Westminster. She leads a research team in glycobiology, molecular biology and bioinformatics and is actively involved with enabling research in clinical trials between academics, industry and Primary Care Trusts.Michelle McCulley has a background in human genetics and experience teaching a broad range of students and health professionals, she is currently a Senior Teaching fellow at the Peninsula Medical School.