Evaluation of Drug Candidates for Preclinical Development

Chao Han 지음

Wiley 2010년 01월 06일 출간

작품소개

책소개

Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug development. This is an enlightening reference for scientists, medicinal chemists, and others working in drug discovery.

목차

PREFACE. CONTRIBUTORS. 1. INTRODUCTION (Charles B. Davis). 2. PHARMACOKINETICS IN PRECLINICAL DRUG DEVELOPMENT: AN OVERVIEW (Dion Brocks). 3. THE ROLE OF MEMBRANE TRANSPORTERS IN DRUG DISPOSITION (Fanfan Zhou, Peng Duan, and Guofeng You). 4. CYTOCHROME P450: STRUCTURE, FUNCTION, AND APPLICATION IN DRUG DISCOVERY AND DEVELOPMENT (Ramesh B. Bambal and Stephen E. Clarke). 5. THE ROLE OF DRUG METABOLISM AND METABOLITE IDENTIFICATION IN DRUG DISCOVERY (Xiangming Guan). 6. PROTEIN BINDING IN DRUG DISCOVERY AND DEVELOPMENT (Vikram Ramanathan and Nimish Vachharajani). 7. PREDICTION OF THE PHARMACOKINETICS IN HUMANS (Chao Han and Ramesh Bambal). 8. PHARMACEUTICS DEVELOPABILITY ASSESSMENT (Lian Huang, Jinquan Dong, and Shyam Karki). 9. SAFETY ASSESSMENT IN DRUG DISCOVERY (Vito G. Sasseville, William R. Foster, and Bruce D. Car). 10. ASSESSMENT OF STRATEGIES UTILIZED TO MINIMIZE THE POTENTIAL FOR INDUCTION OF ACQUIRED LONG QT SYNDROME AND TORSADE DE POINTES (Khuram W. Chaudhary and Barry S. Brown). INDEX.

출판사 서평

"This is a useful reference source for those new to, or aspiring to join the pharmaceutical industry, for academics, and for students of pharmacy and pharmaceutical sciences." (Chromatographia, 1 December 2010) "In conclusion, the book brings the areas of ADME, toxicology and pharmaceutical science together to describe the approaches used to select safe compounds with the required pharmacokinetic and physiochemical properties for progressing into clinical development". (British Toxicology Society, Winter 2010)

작가정보

저자(글) Chao Han

저자 : Chao Han
Chao Han, PHD , is Associate Director of Pharmacokinetics, Modeling and Simulation, Clinical Pharmacology Sciences, Centocor RD. He has been working in drug discovery and early development for more than ten years, published over thirty research articles in peer-reviewed journals, and written three book chapters. Charles B. Davis, PHD , heads Drug Metabolism and Pharmacokinetics for the cancer Metabolism Drug Discovery Unit within Cancer Research at GlaxoSmithKline. He has more than twenty years experience in preclinical and clinical development and has served on the leadership teams of three of GSK's Centers of Excellence in Drug Discovery. Binghe Want, PHD , is Professor and Georgia research Alliance Eminent Scholar in Drug Discovery in the Department of Chemistry, Georgia State University and Georgia cancer Coalition Distinguished Scientist. He also serves as editor in chief of Medicinal research Reviews and is lead editor of Drug Delivery: Principles and Applications (Wiley).