Searching for Molecular Solutions

Ian S. Dunn 지음

Wiley 2010년 01월 05일 출간

작품소개

책소개

A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of bothEmpirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery.Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores:The differing modes of molecular discoveryBiological precedents for evolutionary approachesDirected evolutionary methods and related areasEnzyme evolution and designFunctional nucleic acid discoveryAntibodies and other recognition moleculesGeneral aspects of molecular recognitionSmall molecule discovery approachesRational molecular designThe interplay between empirical and rational strategies and their ongoing roles in the future of molecular discoverySearching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspectsof molecular discovery, as well as the thought processes behind experimental approaches.Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

목차

Acknowledgments.Introduction.1 If It Works, it Works: Pragmatic Molecular Discovery.Overview.Three Ways of Discovery.The Three Wise (Serendipitous) Men and Other Stories.An Empirical Fable.Productively Applying Empiricism.Screening versus Selection.How to be a Librarian.Demon-strating the Power of Empirical Screening and Selection.Dreaming of Pandemonium: a Universal Molecular Space.Mode of Molecular Discovery.The Borderland of Rational Design.2 Empirical Miracles: Nature&-s Precedents for Empirical Solutions.Overview.Evolution Itself.Evolution: Natural and Artificial.To Opine on Design.Natural Evolution at Work.The Raw Materials: Diversity Enough and Time.GOD from Mutation.GOD from Recombination and Other Things.A Sexual Interlude.Doubling Up and Reassorting.Lateral Thinking.The Process: Old Ideas and Newer Wrinkles.The Marks of Lamarck?Evolution by Order?Orderly Beginnings.The Arrow of Complexity?Drivers of Complexity.Complexity and Molecular Discovery.Molecules of Evolution and Design Boundaries.Evolving Proteins.Enzymatic Bounty.Combinatorial Catalysis and Its Helpers.Enzymes to the Limit.Absent by Irreducibility, or Lack of an Access Route?Food for Evolutionary Thought.3 Evolution&-s Gift: Natural Somatic Diversification and Molecular Design.Overview.Immune Systems: a Biological Fundamental.The Selfish Scheme.The Xenobiotic "Immune System" and Beyond.Innately Selfish.How to Shoot Moving Targets.The Empirical Basis of the Adaptive Immune System.The Evolved GOD of the Adaptive Immune System.The T Cell Repertoire and Its Special GOD.The Range and Utility of Adaptive Immunity.Antibodies and Molecular Recognition in General.Selfishness Revisited.Antibody Libraries and Iterative Selection: Natural and Artificial.Iteratively Speaking.Such Selfish Systems Send Selfless Sermons

출판사 서평

"This is a valuable resource that compares empirical discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Scientists, professionals, and students interested in general aspects of molecular discovery will find this book extremely useful." (Doody's, 19 August 2011)&

작가정보

저자(글) Ian S. Dunn

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Ian S. Dunn, PhD, is the Director of Research at Cytocure, LLC, in Beverly, Massachusetts. In keeping with the scope of this book, he has a diverse background in immunology, cell and molecular biology, and biotechnology. His current research focuses on antigen gene regulation in melanoma cells.