Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside

elsevier 2021년 09월 23일 출간

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Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches.？ The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases

Epidemiology of Bone Cancer 1. Osteoarchaeology: lessons to learn from the past 2. Epidemiology of primary bone tumors and economical aspects of bone metastases Models of Bone Cancers and Technical Aspects Animal Models 3. Animal models of bone sarcomas 4. In vivo models used in studies of bone metastaes 5. Zebrafish models for studying bone tumors Mathematic models and machine learning 6. Use of machine learning in bone cancers 7. Artifical intelligence for bone cancer imaging Preparation of tissue samples: technical aspects 8. Technical aspects: how do we best prepare bone samples for proper histological analysis? Bone Microenvironment and Bone Cancer Bone niche 9. Bone niche and bone metastases 10. Bone: a fertil soil for tumor development 11. Osteomimicry: old concepts and new findings Dialog between cancer cells and bone cells 12. Role of mesenchymal stem cells in bone cancers, initiation, propagation and metastasis 13. Technical approaches for studying the communications between osteocytes and cancer cells 14. Osteocytes and bone cancers 15. Immune functions of osteoclasts: new insights for bone cancers 16. Immune infiltrate in bone sarcomas 17. Macrophages and pathophysiology of bone cancers Mediators of cell communications 18. Growth factors, cytokines and pediatric malignant primary bones tumors 19. The role of NFkB in bone cancer 20. TGF-beta and bone cancers: a specific focus 21. Extracellular vesicles, tumor growth and metastatic process 22. Connexin43 and development of primary bone tumors : osteosarcoma and Ewing？？s sarcoma 23. The role of endocannabinoid system in bone cancer Metabolism 24. Impact of the microenvironment acidosis on bone cancers 25. Hypoxic niche and bone cancers 26. Metabolism and bon

Praise for the Previous Editions: "...a comprehensive description of bone tumors from basic to clinical aspects by the most recent data available...specifically useful to medical students and scientists, health professionals, researchers and teachers working in the osteo-articular field." --Anticancer Research "Reviewing the current advances in the progression and therapeutic approaches to bone cancer is an extremely challenging task. Bone cancer is not a single disease; rather, it is a field comprising a diverse and complex range of malignancies, from primary bone tumors of stromal cell origin, to hematopoietic malignancies and secondary metastatic bone disease. Dominique Heymann has assembled an exciting, comprehensive and up-to-date series of reviews contributed by experts in the basic and clinical aspects of bone research. In the past decade, our understanding of cancers involving bone has increased tremendously, underpinned by advances in the cellular, molecular and biochemical mechanisms of bone cell interactions in health and disease, together with advances in genetics, diagnostics, imaging and therapeutic strategies. All these aspects are covered in this timely volume, which will galvanize further cooperative efforts in the coming years between basic researchers, oncologists and pathologists towards understanding the causes of different bone cancers and translating this knowledge into the clinic." --Agi E. Grigoriadis, PhD, Departments of Craniofacial Development and Orthodontics, King's College London, United Kingdom "Our understanding of bone biology and diseases has strikingly progressed in the last decade. In parallel, the processes that lead to various forms of cancer have been further unraveled and the mechanisms leading to metastatic spread further explored. In this book, Dr. Heymann has gathered some of the world experts on these subjects to explore the cutting edge where these fields merge in the context of bo

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