Neurotherapeutics in the Era of Translational Medicine

Richard A. Smith , Brian K. Kaspar , Clive N. Svendsen 지음

elsevier 2020년 12월 09일 출간

작품소개

책소개

For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis??, spinal muscular atrophy, multiple sclerosis, Parkinson??s disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it.Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disordersDiscusses important issues in clinical trials such as design and ethical issuesWritten for neuroscientists, neurologists and pharmacologists

목차

1. Development of a Molecular Therapy for the Treatment of Familial ALS: The SOD-1 Mutation2. Unraveling the Complicated Biology of C9ORF in ALS: Guide to Treatment3. A Gene-Based Therapy for the Treatment of Spinal Muscular Atrophy4. From Uncovering the Mechanism of Transthyretin Aggregation to the Drug Tafamidis for Ameliorating Neurodegeneration and Cardiomyopathy5. Combining cell and gene therapy approaches for Parkinson??s disease and ALS6. Parkinson??s Disease: Genetic-driven Therapeutic Approaches7. Neural Stem Cell-Mediated Brain Tumor Therapy8. Advances in the Treatment of Migraine9. The Treatment of Multiple Sclerosis10. Advances in Treating Myasthenia Gravis11. The Endocannabinoid System as a Target for the Treatment of Neurological Disorders12. Identification of Biomarkers for Diagnosing and Monitoring Therapy in the Treatment of Neurologic Disorders13. 3D Alzheimer??s Disease in a Dish: Implications for Drug Discovery14. Improving Clinical Trial Efficiency with Machine Learning Models of Disease Progression15. Positron Emission Tomography Imaging Agents for Evaluating the Pathologic Features of Alzheimer??s Disease and Drug Development 16. Repurposing FDA Approved Pharmaceuticals: The Development of Nuedexta17. Ethical Considerations in the Era of Translational Medicine18. Government Efforts to Promote the Development of Neurotherapeutics for the Treatment of Neurological Diseases19. Novel strategies for funding the development of therapy for brain diseases

작가정보

저자(글) Richard A. Smith

저자(글) Brian K. Kaspar

저자(글) Clive N. Svendsen