Principles of Bone Biology

John P. Bilezikian , T. John Martin , Thomas L. Clemens , Clifford Rosen 지음

elsevier 2019년 09월 02일 출간

작품소개

책소개

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science??we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end,??Principles of Bone Biology??was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science. This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders.

목차

PART I Basic Principles A. Cell Biology 1. Endochondral and Intramembraneous Bone Development; 2. Mesenchymal Stromal Cells; 3. Hematopoietic-Bone Cell Interactions; 4. Osteoblasts; 5. Osteoclasts; 6. Osteocytes; 7. Transcriptional Control of Osteoblast Differentiation; 8. Wnt Signaling and Bone Cell Activity; 9. Vascular and Nerve Interactions; 10. Coupling of Bone Formation and Resorption; 11. Bone Remodeling; 12. Aging and Bone B. Biochemistry 13. Type I Collagen Structure, Synthesis, and Regulation; 14. Collagen Cross-Linking and Metabolism; 15. Noncollagenous Bone Matrix Proteins (including osteopontin); 16. Bone Proteinases; 17. Integrins and Other Cell Surface Attachment Molecules of Bone Cells; 18. Intercellular Junctions and Cell??Cell Communication in the Skeletal System C. Bone Remodeling and Mineral Homeostasis 19. Histomorphometric Analysis of Bone Remodeling; 20. Phosphorus Homeostasis and Related Disorders; 21. Magnesium Homeostasis; 22. Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lanthanum, Lead, Silicon, and Strontium; 23. Biology of the Extracellular Ca2+-Sensing Receptor D. Endocrine and Paracrine Regulation of Bone 24. Parathyroid Hormone: Molecular Biology; 25. Paracrine PTHrP in Bone: Physiology and Pharmacology; 26. Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System and Vascular, Cardiovascular, and Neurological Actions of Parathyroid-Related Protein; 27. PTH and PTHrP Actions on Kidney; 28. Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein; 29. 1慣,25(OH)2 Vitamin D3Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses; 30. Vitamin D Gene Regulation; 31. Noncalcemic Actions of Vitamin D; 32. Cellular Actions of Parathyroid Hormone; 33. Calcitonin peptides; 34. Regulation of Bone Remodeling by Central and Peripheral Nervous System

출판사 서평

Review of the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

작가정보

저자(글) John P. Bilezikian

저자(글) T. John Martin

저자(글) Thomas L. Clemens

저자(글) Clifford Rosen