The End of Alzheimer s The Brain and Beyond

Thomas J. Lewis , Clement L. Trempe 지음

elsevier 2017년 05월 24일 출간

작품소개

책소개

The End of Alzheimer??s: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer??s outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer??s disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer??s outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer??s, and will hopefully redirect many into new avenues of cellular research and discovery. Comprehensive literature-based summary of the current state of molecular Alzheimer??s disease researchDetails the shortcomings of the prevailing model and therapeutics in developmentReviews blood-based biomarkers for Alzheimer??s and their link to amyloid- and Tau-independent causes outside the brainDescribes the tissues outside the brain impacted by Alzheimer??s and the underlying molecular causesExplains the whole-body risks associated with Alzheimer??s, along with concomitant measures to slow or prevent the diseaseProvides a protocol to properly research, evaluate, measure, diagnose, and potentially treat Alzheimer??s patients

목차

1. Is it Alzheimer??s? 2. The Amyloid Cascade Hypothesis *Chapter includes new information on failed drugs based on the amyloid hypothesis, as well as corroborating evidence that amyloid may be protective. 3. Diagnosis of Alzheimer??s 4. Molecular Causes and Research *Updated chapter 5. Can Medicine Save You? *This will include a new section on medical care and outcomes based on The Organisation for Economic Co-operation and Development (OECD). They compare costs on healthcare spending and outcomes. America spends the most, by far, but is near the bottom of the 35 OECD countries on essentially every measure of health. This shows a strong inverse cause/effect between healthcare implementation / spending and health outcomes in a drug-based healthcare system. 6. A New Diagnostic Paradigm ?? The Molecular Eye *Some updates as the eye is gaining traction as a diagnostic modality. 7. Inflammation ?? Friend or Foe? *Minor but important updates: With more experts saying that infection is part of AD causation, the cause of inflammation is becoming clearer. 8. Alzheimer??s Beyond the Brain ?? Molecular Research in the Body *Minor but important updates: There is much new research linking metabolic conditions to AD, and another new finding is the connection between the gut and Alzheimer??s. That too will be included. 9. Does Infection Cause Alzheimer??s? *This is updated based on significant new research published in 2016. 10. Alzheimer??s Disease Prevention *This has been updated based on infection and the gut becoming more mainstream. 11. Differential Diagnosis toward a Cure for Alzheimer??s Appendix 1: Signs, symptoms, and stages of Alzheimer??s Appendix 2: Alzheimer??s Research at the Cellular Level Appendix 3: Concept of a Medical "Cure" Appendix 4: Alzheimer??s Disease Statistics Appendix 5: Eye and Whole Body Diseases

작가정보

저자(글) Thomas J. Lewis

저자(글) Clement L. Trempe