Models of Seizures and Epilepsy

Alsa Pikanen , Paul Buckmaster , Aristea S Galanopoulou , Solomon L. Moshe , DVM , PhD 지음

elsevier 2017년 06월 14일 출간

작품소개

책소개

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.Provides a comprehensive reference detailing animal models of epilepsy and seizureOffers insights on the use of novel technologies that can be applied in experimental epilepsy researchEdited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiquesComments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

목차

Introduction 1. What can we model? 2. Comparative biology and species effects on expression of epilepsy 3. Strain effects on expression of seizures and epilepsy 4. Good welfare practice in modeling seizures and epilepsy 5. Ethics in the Use of Animal Models of Seizures and Epilepsy 6. Regulatory aspects of drug development 7. Use of animal models for epilepsy research and therapy development Technical and methodological issues 8. Monitoring for Seizures in Rodents 9. Behavioral characterization and scoring of seizures in rodents 10. Seizure mimics 11. Characterization of pathology 12. Monitoring cardiorespiratory and other physiological parameters during seizures in small animals 13. Behavioral and cognitive testing procedures in animal models of epilepsy 14. In vivo Imaging in rodents In vitro and in silico models 15. Hippocampal in silico models of seizures and epilepsy 16. Neocortical/thalamic in silico models of seizures and epilepsy 17. iPS cells, stem cells 18. Hippocampus in vitro 19. Thalamus and cortex in vitro 20. Brain slices from human resected tissues 21. Organotypic Hippocampal Slice cultures as a Model of Post-traumatic Epileptogenesis 22. The in vitro isolated guinea pig brain in the study of ictogenesis Non-mammalian in vivo models? 23. Nematode C. elegans: Genetic Dissection of Pathways Regulating Seizure and Epileptic-like Behaviors? 24. Drosophila 25. Xenopus laevis 26. Zebrafish models of epilepsy and epileptic seizures Naturally occurring seizures and epilepsies in animals 27. Veterinarian??s perspective 28. Naturally occurring epilepsy and status epilepticus in dogs 29. Naturally Occurring Temporal Lobe Epilepsy in Cats 30. Naturally occurring epilepsy and status epilepticus in Sea lions 31. Baboon Model of Genetic Generalized Epilepsy 32. Genetic Models of Reflex Epilepsy and SUDEP in Rats and Mice 33. Genetic models of absence epilepsy in rats and mice In vivo

작가정보

저자(글) Alsa Pikanen

저자(글) Paul Buckmaster

저자(글) Aristea S Galanopoulou

저자(글) Solomon L. Moshe

저자(글) DVM

저자(글) PhD