Stem Cell and Gene Therapy for Cardiovascular Disease

Emerson C. Perin , Leslie W. Miller , Doris Taylor , James T. Willerson 지음

elsevier 2015년 08월 28일 출간

작품소개

책소개

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic.

As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials.

Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic.

• Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials
• Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis
• Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI
• Covers the prevailing opinions on how to harness the body??s natural repair mechanisms
• Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

목차

Introduction: Regenerative Medicine for Cardiovascular Disease
Chapter 1: Introduction and Overview of Stem Cells
Chapter 2: Mechanistic Insights from Pathologic Perspective
Chapter 3: Large Animal Models to Study Stem Cell Therapy
Chapter 4. Evolution of understanding of the mechanisms of repair
Chapter 5: Impact of Age on Stem Cell Function
Chapter 6: Bone Marrow Mononuclear Cells
Chapter 7: Chronic Limb Ischemia
Chapter 8: Chronic/Refractory Angina
Chapter 9: Acute Myocardial Infarction
A. European Experience
B. US Experience
Chapter 10: Chronic Ischemic Heart Failure
Chapter 11: Adipose Tissue
Chapter 12: Overview of MSCs????
Chapter 13: Allogeneic vs Autologous Source: Comparative Effects
Chapter 14: Use of MSCs for AMI
Chapter 15: Combined Cell Strategies
Chapter 16: Heart Failure
Chapter 17:? C-Kit+ cells
Chapter 18:? Cardiospheres
Chapter 19:? Umbilical Cord, Placenta, Endometrium
Chapter 20:? Genetic Engineering of Fibroblasts to Cardiomyocytes
Chapter 21:? Transformation to inducible Pleuripotent Stem Cells
Chapter 22:? Transformation to MAPC's
Chapter 23.? Transcoronary and Endocardial
Chapter 24.? Retrograde and Epicardial
Chapter 25.? Epicardial Patch
Chapter 26.? Matrix Scaffolds
Chapter 27.? Matrix plus cells
Chapter 28.? Biomaterial: Alginate
Chapter 29:? Organogenesis
Chapter 30:? Pre-clinical Identification of target genes
Chapter 31:? SERCA-2a gene for recovery of inotropic function
Chapter 32:? SDF-1 Gene for Heart Failure Non-Inotropic Mechanisms
Chapter 33:? Gene Therapy for Angiogenesis: Chronic Limb Ischemia
Chapter 34:? Stem Cells Target Gene Transfected Stem Cells
Chapter 35:? CCTRN: Past, Present, and Vision for the Future
Chapter 36:? Signature of Responders-lessons from Bio-Repository
Chapter 37:? Adjunctive therapy with LVADs for Recovery
Chapter 38:? Trials in Non-Ischemic Heart Failure

작가정보

저자(글) Emerson C. Perin

저자(글) Leslie W. Miller

저자(글) Doris Taylor

저자(글) James T. Willerson

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