The Comprehensive Sourcebook of Bacterial Protein Toxins

Joseph E. Alouf , Daniel Ladant , Michel R. Popoff 지음

elsevier 2015년 06월 04일 출간

작품소개

책소개

The Comprehensive Sourcebook of Bacterial Protein Toxins 4^th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.

• Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them.
• Focused chapters on toxin applications and common properties or general features of toxins.

목차

1. Evolutionary Aspects of Toxin-Producing Bacteria
2. Mobile Genetic Elements and Pathogenicity Islands Encoding Bacterial Toxins
3. Toxin Secretion Systems
4. Diphtheria Toxin
5. Pseudomonas aeruginosa Toxins
6. Bordetella Proteins Toxins
7. Cholera Toxin, Escherichia coli Thermolabile Enterotoxin and Other Vibrio cholerae Enterotoxins
8. Vibrio parahaemolyticus Virulence Determinants
9. Salmonella Toxin and Virulence Factors
10. The Shiga Toxins
11. Clostridial Neurotoxins: Cellular and Molecular Actions
12. Clostridial Neurotoxins: Uptake and Transport
13. Bacillus anthracis Toxins
14. ADP-Ribosylating Toxins Modifying the Actin Cytoskeleton
15. Large Clostridial Cytotoxins Modifying Small GTpases: Structure Aspects
16. Large Clostridial Cytotoxins Modifying Small GTpases: Cellular Aspects
17. Pasteurella multocida Toxin
18. Deamidating Toxins
19. Helicobaster pylori Vacuolating Toxin
20. Bacterial Genotoxins
21. Basic Mechanism of Pore-Forming Toxins
22. Membrane-Damaging and Cytotoxic Phospholipases
23. Structure and Mode of Action of RTX Toxins
24. Perfringolysin and Related Cholesterol-Dependent Cytolysins
25. Staphylococcus aureus Alpha Toxin and Leucocidins
26. Aerolysin
27. Structural Relationships Between Small ?-Pore-forming Toxins from Clostridium perfringens
28. Clostridium perfringens Enterotoxin
29. Bacillus cereus Enterotoxins
30. Bacillus Insecticidal Toxins
31. Escherichia coli Heat-Stable Enterotoxins
32. Superantigen Toxins
33. Clostridial Toxins in the Pathogenesis of Gangrene
34. Engineering of Botulinum Neurotoxins as Novel Therapeutic Tools
35. Engineering of Bacterial Toxins for Research and Medicine
36. Toxins as Tools in Cell Biology
37. Inhibitors of Toxin Endocytosis
38. Inhibitors of Pore-Form

작가정보

저자(글) Joseph E. Alouf

저자(글) Daniel Ladant

저자(글) Michel R. Popoff