Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Thomas Lehner , Bruce L. Miller , Matthew W. State 지음

elsevier 2016년 06월 07일 출간

작품소개

책소개

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders.? It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience.? In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior.? Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder.??Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.? Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and geneticsIdentifies key concepts, methods, and findingsIncludes coverage of multiple disorders from autism to schizophreniaReviews specific genes associated with disordersDiscusses the genetic architecture of these syndromesExplains how recent findings are influencing the understanding of biologyClarifies the promise of these findings for future treatment

목차

Section 1 The Genome Tools and Methods 1. The Newly Emerging View of the Genome Stephan Sanders 2. Genetic Epidmeiology Kathleen Ries Merikangas 3. Common Variation Mark Daly 4. Rare/Structural Variation Daniel Barrera and Jonathan Sebat 5. Epigenetics and Epigenomics Eric J. Nestler and John Greally 6. Bioinformatics Shaun Purcell 7. Imaging Genomics Paul Matthew Thompson 8. Stem Cell Technology and Genomics Alysson Renato Muotri 9. Association Strategies Benjamin M. Neale 10. The promise of Systems Biology Eric Schadt 11. Gene networks in neuropsychiatric disease Daniel Geschwind 12. Mosaicism Christopher A. Walsh and Saumya Shekhar Jamuar Section 2 A new neuroanatomy 13. Mapping the Molecular Landscape of the Human Brain Nenad Sestan 14. Studying Circuits Stephan Lammel and Robert Malenka 15. Electrophysiological Measurement of Circuits Srikantan S. Nagarajan 16. Imaging the Circuitry of the Human Brain Michael Greicius 17. Neuroimaging Advances in Alzheimer??s Disease Daniel R. Schonhaut and Gil Rabinovici 18. Progressive Supranuclear Palsy and Related Parkinsonian Disorders Jesse A. Brown and William Seeley 19. The Anatomy of Basal Ganglia Circuitry of Behavior Nicholas Au Yong, Adrienne M. Keener, Yvette Bordelon, Carlos Portera-Cailliau and Nader Pouratian 20. Brainstem Circuitry of Behavior Helmut Heisen 21. Apathy ?? Basal Ganglia, Frontal Circuits Mario F. Mendez 22. Emotion Circuitry Robert Wayne Levenson 23. Delusions Georges Naasan 24. Hallucina

작가정보

저자(글) Thomas Lehner

저자(글) Bruce L. Miller

저자(글) Matthew W. State