Development of the Nervous System

Dan H. Sanes , Thomas A. Reh , William A. Harris 지음

elsevier 2000년 06월 07일 출간

작품소개

책소개

Development of the Nervous System presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. Original, artist-rendered drawings combined with clear, concise writing make Development of the Nervous System well suited to anyone approaching this complex field for the first time.Key Features* Provides a synopsis of concepts and experimental strategies* Includes designs of critical experiments that are easy to understand* Outlines the molecular and genetic bases for many developmental events* Presents new information on the function of the developing central nervous system * Richly illustrated with original drawings* Treats the field as an experimental rather than a descriptive science* Written at a level that is appropriate for undergraduates and beyond

목차

Preface.Acknowledgements.InductionDevelopment and Evolution of Neurons. Early Embryology of Metazoans. Neural Tissue Is Derived from Ectoderm. Interactions with Neighboring Tissues Are Required for the Ectoderm to Make Neural Tissue in Many Animals. Interactions among the Ectodermal Cells Control the Process of Neuroblast Segregation. Polarity and RegionalizationRegional Identity of the Nervous System. The Anterior-Posterior Axis and Hox Genes.Hox Gene Function. Signaling Molecules that Pattern the Anterior-Posterior Axis in Vertebrates.Organizing Centers in the Developing Brain. Forebrain Development, Prosomeres and Pax Genes. Dorsal-Ventral Polarity in the Neural Tube. Molecular Basis of Dorsal-Ventral Polarity. Dorsal Neural Tube and Neural Crest. Birth and MigrationCell Cycle Genes Control the Number of Neurons Generated during Development. Cell Interactions Control the Number of Neurons and Glia Generated. Cerebral Cortex Histogenesis.The Subventricular Zone: A Secondary Zone of Neurogenesis. Cerebellar Cortex Histogenesis. Postembryonic and Adult Neurogenesis. Determination and DifferentiationTranscriptional Control of Invariant Lineages. Position and Determination. Multiple Interactions in a Lineage-Based System with Asymmetric Cell Division. The Dominance of Cellular Interactions in the Determination of Drosphila Retinal Cells. Vertebrate Retinogenesis Has a Similar Developmental Strategy. Glial Cell Fate. Fate Decisions in the Vertebrate Neural Crest.Neuronal Fate in the Vertebrate Spinal Cord. Laminar Fate in the Cerebral Cortex. Positional Cues Determine Axonal Projection Patterns. Regulation of Phenotype by the Target. Conclusions. Axon Growth and GuidanceAxonal Navigation. The Growth Cone. The Growing Zon

출판사 서평

"...a truly excellent text that will serve to excite new students in neuroscience and development for years to come...[The authors] imbue their text with enthusiasm, which combined with a scholarly and methodical review of the history of developmental neurology generates a shockingly easy to read and interesting text."--Douglas Kerr, Johns Hopkins Hospital in TRENDS IN NEUROSCIENCES (May 2001)"Clearly and accurately written, beautifully illustrated and thoughtfully organized, this book covers everything from neural induction to the ontogeny of behavior in a style that is easily accessible to students."--RONALD W. OPPENHEIM, Ph.D.Department of Neurobiology & Anatomy, Wake Forest University, Bowman Gray Medical School"The book provides a scholarly review of the past and a carefully pruned view of the present. With relief, I can add that it is written in a clear, accessible style that students will appreciate."--Sally Temple, NATURE NEUROSCIENCE"I certainly intend to make this book required reading for our own graduate course in Developmental Neuroscience."--JOHN L. BIXBY, Neuroscience Program, University of Miami, School of Medicine

작가정보

저자(글) Dan H. Sanes

저자(글) Thomas A. Reh

저자(글) William A. Harris