Cellular and Molecular Neurophysiology

Constance Hammond 지음

elsevier 2008년 02월 06일 출간

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책소개

This third edition is the new, thoroughly revised edition of the only current, established and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titled Cellular and Molecular Neurobiology, the new title better reflects this focus. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field. While the book does cover the important facts, it also presents the background for how researchers arrived at this knowledge to provide a context for the field. It teaches not only how excitable cells work in detail, but also how to construct and conduct intelligent research experiments. This book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.* 80% new or updated material* Fifteen appendices describing neurobiological techniques are interspersed in the text* Now in full color throughout, with more than 400 carefully selected and constructed illustrations* Provides an instructor website with all the images in electronic format, plus additional material

목차

Part I ？？ Neurons: Excitable and Secretory Cells that Establish Synapses.Chapter 1: NeuronsChapter 2: Neuron ？？Glial Cell CooperationChapter 3: Ionic Gradients, Membrane Potential and Ionic CurrentsAppendix 3.1: The active transport of ions by pumps and transporters maintain the unequal distribution of ionsAppendix 3.2: The passive diffusion of ions through an open channelAppendix 3.3: The Nernst equationChapter 4: The Voltage-Gated Channels of Na+ Action PotentialsAppendix 4.1: Current clamp recordingAppendix 4.2: Voltage clamp recordingChapter 5: The Voltage-Gated Channels of Ca+2Action Potentials: GeneralizationAppendix 5.1: Fluorescence measures of intracellular Ca2+ concentrationAppendix 5.2: Tail currentsChapter 6: The Chemical SynapsesAppendix 6.1: Neurotransmitters, agonists and antagonistsAppendix 6.2: Identification and Localization of Neurotransmitters and their ReceptorsChapter 7: Neurotransmitter ReleaseAppendix 7.1: Quantal nature of neurotransmitter releaseAppendix 7.2: The probabilistic nature of neurotransmitter release (the neuromuscular junction as a model)Part 2 ？？ Ionotropic and Metabotropic Receptors in Synaptic Transmission and Sensory Transduction.Chapter 8: The Ionotropic Nicotinic Acetycholine ReceptorsAppendix 8.1: The neuronal nicotinic receptorsChapter 9: The Ionotropic GABAA ReceptorAppendix 9.1: Mean time and mean burst duration of the GABAA single-channel currentAppendix 9.2: Non-invasive measurements of membrane potential and of the reversal potential of the GABAA current using cell-attached recordings of single channelsChapter 10: The Ionotropic Glutamate ReceptorsChapter 11: The Metabotropic GABAB ReceptorsChapter 12: The Metabotropic Glutamate ReceptorsPart 3 ？？ Somato-Dendritic Processing and Plasticity of Postsynaptic Potentials.Chapter 13: Somato-Dendritic Processing of Postsynaptic PotentialsI: P

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"In its third internationally acclaimed edition, this textbook provides an unrivaled account of the basic foundations of molecular and cellular neurophysiology. For those of us who were inclined to believe that the unprecedented development of neuroscience made neurophysiology disposable, Constance Hammond proves us with conviction and elegance that this is just not the case!"-Dr. Robert Dantzer, Professor of Psychoneuroimmunology, Integrative Immunology and Behavior Program University of Illinois at Urbana-Champaign"...a very fluid and self consistent read which should be of interest to neophytes and advanced students alike."-Jean-Marc Fellous, Professor Psychology, Neuroscience, Cognitive Sciences, and Applied Mathematics, University of Arizona, Tucson"A particularly strong feature of the book is that most of the exposition is driven by data from original experiments, supplying many figures that offer a ready-made basis for lectures (figures are available on the instructor's website)." Jim Belanger, Department of Biology, West Virginia University"More than any similar volume that I have come across in recent years, this one has the potential of luring students of neuroscience and even students from other fields to build a career in neurophysiology."Gy철rgy Buzs찼ki, M.D., Ph.D., Board of Governors Professor, Center for Molecular and Behavioral Neuroscience, Rutgers University"...this book is a very precious and unique tool, ideal for students with a strong interest in neuroscience." --Jean-Francois Perrier, Institute of Neuroscience and Pharmacology, University of Copenhagen, Denmark"This is an outstanding book that I will definitely recommend to my students." --Peter Somogyi, Oxford University, United Kingdom

작가정보

저자(글) Constance Hammond