The Practice of Medicinal Chemistry

Camille Georges Wermuth 지음

elsevier 2003년 06월 11일 출간

작품소개

책소개

Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug discovery industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The book reviews practical aspects of Medicinal Chemistry, emphasising the daily problems met by the medicinal chemist when dealing with lead discovery/identification methodologies, with structure-activity relationship studies aimed to scale up potency and target selectivity, and when optimising pharmacokinetic and pharmaceutical properties by means of ultimate chemical modifications.This is the second edition of The Practice of Medicinal Chemistry, the first edition being published in February 1996. The new edition is thoroughly revised, with around 30% new material, and refocussed to reflect the recent developments in genomics, proteomics, high throughput screening of compounds and drug solubilisation. An effort has been made to remove the overlap that exists in the previous edition and four new chapters have been introduced.* Written by experts in the field* The first edition of The Practice of Medicinal Chemistry, published in 1996, was nicknamed 'The Bible' by medicinal chemists.* The only available book dealing with the practical aspects of medicinal chemistry, from conception of the molecules through to the production of drugs* An essential practical handbook for the medicinal chemist, working in the pharmaceutical industry, with little or no background in medicinal chemistry-a complete guide to the drug discovery process.

목차

Foreward.Preface.A Brief History Of DrugsFrom Plant Extracts To DNA TechnologyMedicinal Chemistry: Definition And Objectives, The Three Main Phases Of Drug Activity, Drug And Diseases ClassificationsMeasurement And Expression Of Drug EffectsDrug Targets: Molecular Mechanisms Of Drug ActionStrategies In The Search For New Lead Compounds Or Original Working HypothesesNatural Products As Pharmaceuticals And Sources For Lead StructuresBasics Of Combinatorial ChemistryThe Contribution Of Molecular Biology To Drug DiscoveryElectronic Screening: Lead Finding From Database MiningHigh-Speed Chemistry Libraries: Assessment Of Drug-LikenessWeb Alert ？？ Using The Internet For Medicinal ChemistryMolecular Variations In Homologous Series: Vinylogues And BenzologuesMolecular Variations Based On Isosteric ReplacementsRing TransformationsIntroduction Of Conformational Restriction And/Or Steric HindranceIdentical And Non Identical Twin DrugsOptical Isomerism In DrugsApplication Strategies For The Primary Structure-Activity Relationship ExplorationSpecific Substituent GroupsThe Role Of Functional Groups In Drug-Receptor InteractionsCompound Properties And Drug QualityQuantitative Approaches To Structure-Activity RelationshipsStructural Aspects Of Drug Action IPharmacophore Identification And Receptor MappingThree-Dimentional Quantitative Structure-Property RelationshipsProtein Crystallography And Drug DiscoveryProtein Comparative Modelling And Drug DiscoveryThe Transition From Agonist To Antagonist Activity: Symmetry And Other ConsiderationsDesign Of PeptidomimeticsThe Fate Of Xenobiotics In Living OrganismsBiotransformation ReactionsChemical Mechanisms Of ToxicityBasic Knowledge For Designing Safer DrugsDesigning Prodrugs And Bioprecursors Macromolecular Carriers For Drug TargetingPreparation Of Water Soluble Compounds Through Salt F

출판사 서평

"...it serves as an excellent introduction to those just starting a career in medicinal chemistry."-John W. Ellingboe, Wyeth Research, New York"The Practice of Medicinal Chemistry is highly recommended for medical libraries and academic libraries that support a chemistry program." -E-STREAMS (May 2004)"...capture[s] the whole spectrum of activities associated with both the theory and practice of rational drug design." -BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2003)

작가정보

저자(글) Camille Georges Wermuth